Is random mutation more rational?

This publication has 6 references indexed in Scilit:

• Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents
  Nature Biotechnology, 1996
• Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide
  Protein Engineering, Design and Selection, 1996
• The Catalytic Performance of Pig Pancreas Lipase in Enantioselective Transesterification in Organic Solvents
  Biocatalysis and Biotransformation, 1995
• Surface charge substitutions increase the stability of .alpha.-lytic protease in organic solvents
  Journal of the American Chemical Society, 1991
• [27] Modification of enzyme catalysis by engineering surface charge
  Published by Elsevier ,1991
• Engineering enzymes for non-aqueous solvents
  Trends in Biotechnology, 1990