Molecular mechanisms of photocarcinogenesis
- 1 January 2002
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 7 (1-3) , d765-83
- https://doi.org/10.2741/matsumur
Abstract
Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto-oncogenes and tumor suppressor genes, and UV-induced immunosuppression. The understanding and further investigation of photocarcinogenesis is critical to the development of effective prevention and intervention strategies for human skin cancer.Keywords
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