Ly‐1 b cells and disease activity in (new zealand black × new zealand white)f1 mice

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Abstract
The treatment of female (New Zealand black × New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation‐treated mice also showed a marked reduction of Ly‐1 B cells, which lasted up to 3 months. The subsequent return of Ly‐1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti‐DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly‐1‐ (CD5‐) splenic B cell population.