INFLUENCE OF BASAL PLASMA GLUCOSE CONCENTRATION ON GLUCAGON RESPONSE TO ARGININE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 11, 53-56
Abstract
Plasma glucose and glucagon concentrations were measured in the portal vein of healthy, anesthetized pigs submitted to an i.v. arginine infusion test. A monophasic glucagon response was observed in all pigs, the peak glucagon value being reached within an average of 5 min after the beginning of the infusion. The glucagon response, expressed as the incremental area below the hormone concentration curve, correlated inversely with the plasma glucose concentration before the start of arginine infusion (r = 0.78) (P < 0.05) indicating that glucose is a potent inhibitor of arginine-induced glucagon secretion in pigs.

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