Maintenance of Physiologic Temperatures by Halogenated Corticoid in Adrenalectomized Mice Given Brucella Somatic Antigen

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Abstract
Brucella somatic antigen (endotoxin) was given intraperitoneally to 5 groups of adrenalectomized male CBC mice, kept under standard conditions. Four of these groups received additional treatment consisting of either 2.5[mu]g or of 25.0[mu]g of 9 alpha-fluorohydrocortisone acetate or of cortisone acetate. The rectal temperatures of these mice were measured by means of a thermistor-bridge circuit at 50-minute intervals for 6 hours. Mice given only the endotoxin showed a progressive decrease of the rectal temperature to the level of the room temperature. Both 9 alpha-fluorohydrocortisone acetate and cortisone acetate protected against this hypothermia induced by endotoxin; the former compound protected decisively more than the latter.

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