Lithium benzenetellurolate-induced Reformatsky-type reaction in the presence of cerium trichloride
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 17,p. 1963-1965
- https://doi.org/10.1039/p19930001963
Abstract
Reformatsky-type reactions with PhTeLi in the presence of CeCl3 proceeded smoothly under mild conditions. The PhTeLi–CeCl3 reagent was particularly efficient for the reactions of sterically hindered and enolizable ketones; in the absence of CeCl3 unsatisfactory yields of the desired β-hydroxy ketone were obtained. It is assumed that CeCl3 reactions involve a cerium enolate intermediate. The stereoselectivity of the reaction between ethyl 2-bromopropionate and benzaldehyde is also described.Keywords
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