The synthesis of indan-1-ones and isocoumarins
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 471-479
- https://doi.org/10.1039/p19810000471
Abstract
A flexible synthetic route leading via indan-1-ones to variously methylated and oxygenated isocoumarins is described. The indanones are prepared by alternative routes involving intramolecular Friedel–Crafts cyclisation of aryl-propionic acids or pericyclic ring closure of acrylophenones. The influence of substitution on the rate of the pericyclic reaction is assessed.This publication has 0 references indexed in Scilit: