SOLUBLE FACTORS IN TOLERANCE AND CONTACT SENSITIVITY TO DNFB IN MICE .2. GENETIC REQUIREMENTS FOR SUPPRESSION OF CONTACT SENSITIVITY BY SOLUBLE SUPPRESSOR FACTOR
- 1 January 1977
- journal article
- research article
- Vol. 119 (5) , 1773-1777
Abstract
Active suppression of contact sensitivity to DNFB [dinitrofluorobenzene] in mice is mediated by a soluble suppressor factor (SSF) which is released in vitro by cultures of LN [lymph node] cells that contain antigen-specific suppressor T [thymus-derived] cells. For SSF-mediated suppression to occur, identity is required among genes in the H-2 complex between the donor SSF and the donor of DNFB-immune LN cells. Identity in the left half or right half of the H-2 complex was sufficient and required. Additional experiments using congeneic strains with intra-H-2 recombinants showed that the genetic homology which was required mapped to genes contained in the H-2K and/or H-2D regions of the H-2 complex.This publication has 11 references indexed in Scilit:
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