Anti‐dsdna and complement profiles as prognostic guides in systemic lupus erythematosus
Open Access
- 1 March 1979
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 22 (3) , 226-235
- https://doi.org/10.1002/art.1780220304
Abstract
Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti-dsDNA titer (expressed in units), and the C1q and C3 levels: when anti-dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti-dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen.This publication has 22 references indexed in Scilit:
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