Nucleotide‐Iron Complexes and Lipid Peroxidation: Mechanisms and Biological Significance

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Abstract
Nucleotide pyrophosphate‐iron complexes (NPP‐Fe), which presumably function in the intracellular transport of iron, may also serve as substrates for cytochrome P450 reductase. The reduction of these complexes via this flavin enzyme leads to the formation of oxygen radicals which have the capacity to initiate peroxidation reactions in phospholipids. It is suggested that the formation of oxygen free‐radicals, catalyzed by iron bound to nucleotides, may contribute to cellular alterations involving membranes as well as other biological constituents.

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