An evaluation of the activity of cephalosporins against Pseudomonas aeruginosa
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 8 (suppl B) , 111-117
- https://doi.org/10.1093/jac/8.suppl_b.111
Abstract
We investigated the in-vitro activity of 14 antibiotics against 200 distinct isolates of Pseudomonas aeruginosa obtained from intensive care patients. Ceftazidime was the most active β -lactam and 16 mg/l inhibited 88% of the strains. Of 55 two-drug combinations, ceftazidime plus tobramycin was the most effective and 98.5% of strains were sensitive. Synergism between these two drugs was demonstrated for 12 of the 23 strains tested. Ceftazidime-inactivating enzymes may be induced in Ps. aeruginosa by cefoxitin.Keywords
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