Observations on Streptomyces Griseus. IV. Induced Mutation and Strain Selection

Abstract
This paper is concerned with some aspects of natural and induced variability in S. griseus, particularly in relation to streptomycin production. Some of the variable characters include the color of spores and degree of sporulation; the surface and margin of the colony, as well as colony sectoring; the amt. and color of exudate on the colony surface; and the amt. and color of soluble pigment released into the substratum. In addition, great variation occurs in the amt. of streptomycin produced. Theonormal variation was increased by treatment with u.-v. light (2537 A) and by treatment with (C1CH2CH2)3N (0.005 [image]). No complete correlation between morphological type and streptomycin production could be found. However, strain selection and induced mutation can be used to obtain strains with an increased capacity for producing streptomycin.

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