Overrepresentation of Blood Group Non-Secretors in Adults with Renal Scarring

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Abstract
Host factors are important in the pathogenesis of pyelonephritic renal scarring. The present study used blood group secretor state as a population marker to determine if patients developing renal scarring are a selected subgroup of individuals with urinary tract infections (UTI). Non-secretors represented 15/43 (35%) of the patients with renal scarring but only 7/41 (17%) of the patients without renal scarring (p=0.059 and NS respectively vs. healthy controls 22%). The frequency of non-scretors among P1 phenotype patients with renal scarring was 38% (p=0.05 vs. healthy controls). Among the patients born after the introduction of regular use of antibiotic treatment for UTI the frequency of non-secretors was 55% in the scarred group compared to 13% in the unscarred group (p=0.011). Thus, in this younger group of patients with renal scarring 6/10 (60%) of the non-secretors developed renal scars compared to 5/32 (16%) of the secretors (p2 and 79 ml/minx 1.73 m2, respectively). Whether blood group secretor state also is involved in the scarring process remains to be investigated.