THE PROLIFERATIVE STATE OF EARLY ERYTHROPOIETIC PROGENITOR CELLS (BFU-E) IN HUMAN UMBILICAL-CORD BLOOD - LOW PROBABILITY OF FINDING BFU-E IN DNA-SYNTHESIS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 12  (8) , 650-654
Abstract
The proliferative behavior of early erythropoietic progenitor [erythroid burst forming unit] cells (BFU-E) was investigated in human umbilical cord blood with hydroxyurea and 3H-thymidine suicide experiments. Results indicate that the great majority of these progenitors are normally either in a quiescent state with respect to DNA synthesis or in a prolonged cell cycle experimentally indistinguishable from this state. In this regard, neonatal BFU-E resemble adult circulating BFU-E.