LIPID RELATIONSHIPS IN DIALYSIS AND RENAL-TRANSPLANT PATIENTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 50  (198) , 149-160
Abstract
The relationship of high density lipoprotein cholesterol (HDL-CHOL) to other lipid fractions and the factors influencing post-transplant hyperlipidemia were explored in 28 chronic hemodialysis patients and 20 stable renal allograft recipients. In both groups of patients mean triglyceride (TG) and very low density lipoprotein cholesterol (VLDL-CHOL) were elevated, but total CHOL and low density lipoprotein cholesterol (LDL-CHOL) were elevated only in transplanted patients. HDL-CHOL was uniformly low in dialysis patients irrespective of TG, whereas after transplantation mean HDL-CHOL was normal and varied inversely with TG and VLDL-CHOL. Serum creatinine correlated with TG and VLDL-CHOL in transplant patients, and was inversely related to HDL-CHOL. No factors correlated with CHOL or LDL-CHOL in transplant patients, but these lipids were moderately elevated. Hyperlipidemia in dialysis and transplant patients is not invariable; its importance for atherogenesis remains to be determined.