The use of bacteria producing the aminoglycoside inactivating enzyme ANT-(2'') in an in-vitro model

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Abstract
A series of transconjugants of Eschenchia coli W3110 containing different plasmids coding for the aminoglycoside inactivating enzyme ANT-(2″) were tested in an in-vitro model simulating the concentration time curves of aminoglycosides after intramuscular administration of 80 or 120 mg There was good correlation of the MIC, which ranged from 2 to 32 mg/1, with the killing ability of the drugs. A second dose had no or only little effect on ANT-(2″) producing strains. All strains, although of ‘intermediate’ sensitivity were found to be resistant in the in-vitro model. Only netilmicin could eliminate some of the strains but its activity on ANT-(2″)-positive strains was not as good as on ANT-(2″)-negative ones.

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