Abstract
It has long been known that different people react differently to foreign substances. Over half a century ago it was realized that patients as well as laboratory animals may sicken or die, not from the inherent toxicity of a foreign substance, but from their individual reaction to it. Thus, in contrast to immunity, which involves the mechanisms for preventing or suppressing disease, Clemens von Pirquet,1 in 1906, defined the subject of allergy, which deals with mechanisms of changed bodily reactivity to foreign substances. The most frequent kind of changed reactivity on re-exposure to substances was that known as hypersensitivity, and . . .

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