TYPING OF CYTOPATHIC AND NONCYTOPATHIC BOVINE VIRAL DIARRHEA VIRUS REFERENCE AND CANADIAN FIELD STRAINS USING A NEUTRALIZING MONOCLONAL-ANTIBODY

  • 1 January 1988
    • journal article
    • research article
    • Vol. 52  (1) , 42-45
Abstract
Cytopathic and noncytopathic reference strains as well as Canadian field isolates of bovine viral diarrhea virus were analyzed by neutralization and immunofluorescence tests using a bovine viral diarrhea virus-specific neutralizing monoclonal antibody. Results of reference strains indicated three major antigenic groups: I) NADL-like, II) New York 1-like and III) Oregon C24V-like. Field isolates could be segregated into groups I and II and none could be typed into the group III. It appears that most bovine viral diarrhea virus strains share a common antigen which carries a major neutralization epitope. These characteristics would make this monoclonal antibody a useful reagent for taxonomic and epizootiological studies.