Enzymatic synthesis of cholecystokinin-octapeptide.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (10) , 3915-3919
- https://doi.org/10.1248/cpb.36.3915
Abstract
Cholecystokinin-octapeptide was synthesized by enzymatic condensations of three fragments, without side-chain protection, except for Tyr. Fmoc-Asp-Tyr(SO3Bal/2)-OH, prepared by the concerted action of proteases, followed by pyridinium trifluoroacetylsulfate treatment, was used as the N-terminal fragment. In the final step, the N.alpha.-Fmoc group employed as a sole protecting group was easily removed by base treatment without affecting the SO3 moiety.This publication has 4 references indexed in Scilit:
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