The Influence of Acute Physiological Increments of Cortisol on Fuel Metabolism and Insulin Binding to Monocytes in Normal Humans *
- 1 March 1980
- journal article
- retracted article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 50 (3) , 495-501
- https://doi.org/10.1210/jcem-50-3-495
Abstract
The role of physiological hypercortisolemia in the regulation of fuel metabolism in man was examined during a 5-h primed-continuous infusion of cortisol which raised plasma cortisol levels to 40 μug/dl. Plasma glucose increased by 15–ke and clearance, on the other hand, fell by 15% (P < 0.05) and 30% (P < 0.005), respectively, thereby accounting for cortisol-induced hyperglycemia. Total blood ketones during cortisol infusion increased 3-fold above saline control values (P < 0.01) despite comparable FFA levels in the twogroups. In addition, there was a selective 40% rise in total branched chain amino acids (P < 0.005) during cortisol infusion. These effects of cortisol on glucose, ketone, and amino acid metabolism occurred in the absence of significant changes in the plasma insulin or glucagon concentration. Furthermore, cortisol infusion had no effect on [l25I] insulin binding to circulating monocytes. Our data thus suggest that acute elevations of plasma cortisol have antiinsulin effects in man which may occur independent of alterations in insulin receptors.(J Clin Endocrinol Metab50: 495,1980).Keywords
This publication has 1 reference indexed in Scilit:
- Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and RefeedingJournal of Clinical Investigation, 1978