FACTORS CONTRIBUTING TO VARIABILITY IN DRUG PHARMACOKINETICS. II. DRUG DISTRIBUTION*
- 28 June 2008
- journal article
- review article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 10 (1) , 15-23
- https://doi.org/10.1111/j.1365-2710.1985.tb00713.x
Abstract
Many factors determine the distribution of a drug within the body. All factors may be altered in physiological and pathological states, and this may result in a need to change either the dose of the drug administered or the dosage interval. Changes in plasma protein binding may also alter the interpretation of the relationship between total plasma drug concentration and drug effect, and in such circumstances the free drug concentration may provide a better guide to optimal therapy.Keywords
This publication has 12 references indexed in Scilit:
- Effect of valproate on free plasma phenytoin concentrations.British Journal of Clinical Pharmacology, 1984
- Control of Lidocaine TherapyTherapeutic Drug Monitoring, 1982
- Diazepam and lidocaine plasma protein binding in renal diseaseClinical Pharmacology & Therapeutics, 1982
- Pharmacokinetics of digoxin in patients subjected to the quinidine- digoxin interaction.Published by Wiley ,1981
- Effect of plasma protein and tissue binding on the biologic half‐life of drugsClinical Pharmacology & Therapeutics, 1978
- Intrasubject variation of warfarin binding to protein in serum of patients with cardiovascular diseaseClinical Pharmacology & Therapeutics, 1976
- Plasma binding and the affinity of propranolol for a beta receptor in manClinical Pharmacology & Therapeutics, 1976
- Plasma and Tissue Protein Binding of Drugs in PharmacokineticsDrug Metabolism Reviews, 1976
- A physiological approach to hepatic drug clearanceClinical Pharmacology & Therapeutics, 1975
- Myocardial distribution of digoxin and renal functionClinical Pharmacology & Therapeutics, 1974