Synthesis of (11S)- and (11R)-[11-2H1]porphobilinogen; stereochemical studies on hydroxymethylbilane synthase (PBG deaminase)
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 924-927
- https://doi.org/10.1039/c39850000924
Abstract
(11S)-and (11R)-[11-2H1]Porphobilinogen (PBG) are synthesized and their configurations are established by degradation to a derivative of 2H1-glycine; they are used to prove that when hydroxymethylbilane synthase (PBG deaminase) acts on PBG in the presence of ammonia, aminomethylbilane is formed with overall retention of configuration at the NH2CHD-group.Keywords
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