Short report: interferon‐α decreases 14C–aminopyrine breath test values in patients with chronic hepatitis C

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Abstract
SUMMARY: Objective: To investigate the effect of interferon‐α on cytochrome P‐4 50 dependent microsomal function. Methods: The 14C‐aminopyrine breath test was performed before, during and after a standard dose of interferon‐α (3 000000 units three times per week) was administered for at least six months (nine patients with chronic hepatitis C). Results : Mean aminopyrine breath test values obtained during therapy were significantly lower than either pre‐ or post‐treatment, the degree of reduction varying widely between individuals. Pre‐ and post‐treatment aminopyrine breath test values did not differ significantly. Conclusion: Interferon therapy is associated with a significant and transient inhibition of cytochrome P‐450 activity, which should be taken into account when prescribing concurrent therapy with drugs metabolized by this pathway.