EFFECTS OF PROSTAGLANDIN INHIBITION ON VASOPRESSIN LEVELS IN WOMEN WITH PRIMARY DYSMENORRHEA

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (2) , 206-208
Abstract
Arginine vasopressin (AVP) concentrations in plasma were studied in women with primary dysmenorrhea before and after treatment with naproxen and in healthy control women on the 1st day of menstruation. In the treated group the AVP concentration was about 4 times higher than that in the controls, and the AVP level remained unchanged after almost complete pain relief had been obtained by treatment with the prostaglandin synthesis inhibitor. No significant differences were found between the 2 groups in plasma osmolality and Na concentration on the 1st day of menstruation or in the concentrations of progesterone and estradiol at this time or in the midluteal phase of the preceding menstural cycle. Apparently, increased AVP secretion may play an etiologic role in dysmenorrhea, activating the uterus via a final step of prostaglandin synthesis and release.