Reciprocal Changes, Caused by Insulin and Glucagon, of Adipose Tissue Lipoprotein Lipase in Rats In Vitro
- 1 April 1981
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 13 (04) , 212-213
- https://doi.org/10.1055/s-2007-1019223
Abstract
Effects of insulin and glucagon on lipoprotein lipase activity in rat adipose tissue were studied in vitro. Adipose tissue from normal or streptozotocin-diabetic rats was incubated in Krebs-Ringer bicarbonate buffer for 60 min at 37.degree. C in the presence of heparin and lipoprotein lipase released from the tissue into the incubation medium was measured. Diabetic rats showed markedly low activities of adipose tissue lipoprotein lipase. Insulin (500 .mu.U/ml) increased lipoprotein lipase activity in adipose tissue from diabetic rats. Glucagon (500 pg/ml) decreased the enzyme activity in normal rat adipose tissue. Insulin and glucagon cause reciprocal changes of lipoprotein lipase activity in rat adipose tissue.This publication has 3 references indexed in Scilit:
- SELECTIVE DEFICIENCY OF HEPATIC TRIACYLGLYCEROL LIPASE IN GUINEA-PIGS1979
- Intra- and extracellular forms of lipoprotein lipase in adipose tissueBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- EFFECT OF DIABETES AND INSULIN ON THE ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS*Journal of Clinical Investigation, 1963