Therapeutic effects of clozapine

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Abstract
The double-blind method was used to compare the therapeutic effects of clozapine and chlorpromazine in a sequential cohort of 50 schizophrenic patients with similar demographic characteristics, randomly allocated to 2 groups (experimental and control) of 25 patients each. At the end of the 6 wk trial period, statistically significant differences were found between the 2 groups in both the symptom check-list score and the overall clinical evaluation. Follow-up evaluations conducted at 3 and 4 yr intervals show that the differences between the 2 groups are persistent, which points in the direction of a better and more sustained therapeutic effect of clozapine over chlorpromazine. No discernible ill effects which could be attributed to either drug were detected throughout the 4 yr period.