Identification of nucleus‐encoded F0I protein of bovine heart mitochondrial H+‐ATPase as a functional part of the F0 moiety

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Abstract
The F0I protein of apparent M r 27000, previously characterized [(1988) Eur. J. Biochem. 173, 1–8] as a genuine component of bovine heart F0, has been sequenced and shown to be identical with the nucleus encoded 24668 Da protein characterized earlier [(1987) J. Mol. Biol. 197, 89–100]. It is directly shown by proteolytic cleavage and reconstitution experiments that this protein, denoted here as PVP from the single‐letter codes of the last three residues of the N‐terminus, is involved in proton conduction by F0 and in its sensitivity to oligomycin.