THE EFFECT OF EXTRACTS OF THE ADRENAL GLANDS ON THE RESPIRATION OF ISOLATED BRAIN AND LIVER SLICES

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Abstract
The respiration of brain and liver slices of the rat is inhibited by extracts of the adrenal gland. The degree of inhibition appears to be proportional to the cortin content of the extract and not to any other known factor. The threshold for the inhibitory action is approximately at a cortin conc. of 2 cat units per cc. of medium. The R.Q. of the brain slices was not affected by the extract in any conc. used. Crystalline corticosterone has a depressing action on the respiration of brain slices. The effective conc. of corticosterone is of the same magnitude as the solid matter of the adrenal extracts, although the effect of the corticosterone is somewhat greater. The extracts have the same effect on the respiration of brain slices from adrenalectomized rats. An extract of beef brain (made up in same manner as the adrenal extracts) has a depressing effect on the respiration of brain slices, but is less effective than equivalent quantities of adrenal extract.

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