Epidemiology of Penicillinase-ProducingNeisseria gonorrhoeaeInfections

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Abstract
Auxotyping and serogrouping by coagglutination were used to characterize penicillinase-producing Neisseria gonorrhoeae and penicillinase-negative isolates from the state of Washington, Shreveport (Louisiana), and the Far East. Fifty-four of 75 penicillinase-producing isolates (72 per cent) from Washington required proline for growth and were serogroup W-I (Pro-I), the predominant type of penicillinase-producing strains in the Philippines; none of 86 penicillinase-negative isolates from Washington was Pro-I (P-II); five of 26 penicillinase-negative isolates (19 per cent) from Shreveport were also Pro-II (PN. gonorrhoeae and probably originated from a common source, whereas several types were involved in the multiple-source Washington outbreak, indicating repeated introduction of new strains. (N Engl J Med. 1982; 306:950–4.)