Characterization of Avian Reoviruses Isolated from the Synovia and Breast Blister

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Abstract
Reoviruses Texas, S 1133, UMI 203 and WVU 2937 induced swelling of the foot pad and inflammatory changes in the synovial membranes when inoculated in the foot pad of 2 wk old gnotobiotic chicks. From differences in virus neutralization as measured with geometric mean (R) value, all 4 viruses are subtypes of a single serotype. The cell-associated and cell-released virus growth curves were similar, with a lag phase of about 15 h and a log phase of 15-21 h. Viral RNA synthesis reached a peak in 5 h and was active at 14 h but not at 18 h. In 90 min at 60.degree. C the titer of each virus had decreased about 4 logs10.