Importance of Particle Size in Aerosol Therapy.

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Abstract
A comparison of the effects of 2 different aerosols of the same sympathomimetic drug on heart rate and blood pressure in 4 normal subjects was made. The aerosol from a standard commercial nebulizer, producing particle sizes averaging at least 3.1 [mu] in diameter caused tachycardia and blood pressure elevation. The other aerosol from a D-30 generator producing particles all below 0.5 [mu] in diameter failed to have any systemic effects although it had been shown to relieve bronchoconstriction. The sub-microscopic particles from the D-30 generator produced a larger surface area to dose ratio and were effective in relieving bronchoconstriction even though total dose from the generator was 30 times less than the standard nebulizer for a given number of breaths.

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