An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals
Top Cited Papers
- 16 September 2009
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Research in Toxicology
- Vol. 22 (11) , 1747-1760
- https://doi.org/10.1021/tx900242k
Abstract
The sequence of heterocyclic bases on the interior of the DNA double helix constitutes the genetic code that drives the operation of all living organisms. With this said, it is not surprising that chemical modification of cellular DNA can have profound biological consequences. Therefore, the organic chemistry of DNA damage is fundamentally important to diverse fields including medicinal chemistry, toxicology, and biotechnology. This review is designed to provide a brief overview of the common types of chemical reactions that lead to DNA damage under physiological conditions.Keywords
This publication has 205 references indexed in Scilit:
- Oxygen Free Radical Damage to DNAJournal of Biological Chemistry, 2001
- Principal causes of hot spots for cytosine to thymine mutations at sites of cytosine methylation in growing cells: A model, its experimental support and implicationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999
- Thymidine Hydroperoxides: Structural Assignment, Conformational Features, and Thermal Decomposition in WaterJournal of the American Chemical Society, 1994
- Hydrolysis of N3-methyl-2′-deoxycytidine: Model compound for reactivity of protonated cytosine residues in DNAMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- The influence of N7 substituents on the stability of N7-alkylated guanosinesChemico-Biological Interactions, 1985
- Identification of N5-methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine as a major adduct in rat liver DNA after treatment with the carcinogens, N,N-dimethylnitrosamine or 1,2-dimethylhydrazineBiochemical and Biophysical Research Communications, 1983
- Alkaline opening of imidazole ring of 7-methylguanosine. 1. Analysis of the resulting pyrimidine derivativesChemico-Biological Interactions, 1982
- Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymusBiochemistry, 1980
- O2- and O4-Alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pHBiochemistry, 1978
- Removal of minor methylation products 7-methyl adenine and 3-methylguanine from DNA ofescherichia coli treated with dimethyl sulphateChemico-Biological Interactions, 1976