Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.
- 1 December 1990
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 431 (1) , 505-513
- https://doi.org/10.1113/jphysiol.1990.sp018343
Abstract
Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. Placental clearance for mannitol was 8.7 .+-. 1.1 ml min-1 (mean .+-. S.E.M.), lactulose 6.3 .+-. 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 .+-. 0.5, and inulin 0.98 .+-. 0.1. The permeability data were analysed in terms of restricted diffusion through ''notional'' water-filled pores and found to be incompatible with a single population of uniform pores.This publication has 16 references indexed in Scilit:
- Investigation of cholinesterase in amniotic fluid.BMJ, 1986
- Volumes of distribution of sodium and albumin in the sheep placenta.The Journal of Physiology, 1983
- Transport of polar non-electrolytes across the intact and perfused guinea-pig placentaPlacenta, 1980
- The steady state concentration gradients of an electron-dense marker (ferritin in the three-layered hemochorial placenta of the rabbit.Journal of Clinical Investigation, 1976
- Permeability of the sheep placenta to unmetabolized polar non‐electrolytes.The Journal of Physiology, 1976
- THE ANTENATAL MEASUREMENT OF FETAL URINE PRODUCTIONBJOG: An International Journal of Obstetrics and Gynaecology, 1973
- Permeability of lung capillaries and alveoli to non‐electrolytes in the foetal lamb. With an AppendixThe Journal of Physiology, 1971
- Maternal-fetal urea concentration difference in man: Metabolic significanceThe Journal of Pediatrics, 1971
- Estimation of the equivalent pore dimensions in the rabbit placentaLife Sciences, 1969
- A new method for the determination of inulin in plasma and urineClinica Chimica Acta; International Journal of Clinical Chemistry, 1956