Characterization of microbial mutagens in complex samples—methodology and application
- 1 July 1984
- journal article
- research article
- Published by Taylor & Francis in Critical Reviews in Environmental Control
- Vol. 14 (2) , 91-150
- https://doi.org/10.1080/10643388409381715
Abstract
Methodologies for characterization of mutagens in complex mixtures have been reviewed. The methods discussed include successive fractionation with various solvents, combinations of chemical fractionation and bio‐assay directed analyses and separation with in situ testing using thin layer chromatography or other separation techniques. In all cases the discussions are limited to the Ames Salmonella assay as detection method for mutagenicity. Particular problems in testing complex samples such as bacterial toxicity, synergistic or antagonistic effects are also discussed. Applications of the methods are reviewed. These applications include environmental samples such as airborne particles, water pollutants, and consumer products.Keywords
This publication has 137 references indexed in Scilit:
- Identification of nitroaromatics in diesel exhaust particulate using gas chromatography/negative ion chemical ionization mass spectrometry and other techniquesEnvironmental Science & Technology, 1982
- Multitechnique screening of Chicago municipal sewage sludge for mutagenic activityEnvironmental Science & Technology, 1982
- Characterization of polycyclic ketones and quinones in diesel emission particulates by gas chromatography/mass spectrometryEnvironmental Science & Technology, 1982
- Concentrating organics in water for biological testingEnvironmental Science & Technology, 1981
- Identification and mutagenic properties of some chlorinated aliphatic compounds in the spent liquor from kraft pulp chlorinationEnvironmental Science & Technology, 1981
- Dilution source sampling system.Environmental Science & Technology, 1980
- Identification of organic compounds in a mutagenic extract of a surface drinking water by a computerized gas chromatography/mass spectrometry system (GC/MS/COM)Environmental Science & Technology, 1980
- Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell cultureBiochemical and Biophysical Research Communications, 1977
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Mutagenicity of metronidazole: Activation by mammalian liver microsomesBiochemical and Biophysical Research Communications, 1975