Stabilisation of duplex DNA by 7-halogenated 8-aza-7-deazaguanines
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 18,p. 2017-2018
- https://doi.org/10.1039/a804414g
Abstract
Oligonucleotides containing 7-halogenated 8-aza-7-deaza-2′-deoxyguanosine (c7z8Gd) derivatives such as d(Br7c7z8 G-C)4 8 (Tm = 88 °C) and d(I7c7z8 G-C)4 9 (Tm = 84 °C) are significantly more stable than d(G-C)4 5 (Tm = 59 °C).Keywords
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