Failure to Find Individual Blood Differences in Guinea Pigs or in Mice

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Abstract
Since the discovery of the human blood groups, there have been many attempts to find similar groups in laboratory and domestic animals. The genetic study of such groups would be most interesting. Such studies are evidently now being completed on the rabbit in Castle's laboratory (1). MacDowell and Hubbard (7) failed to find isoagglutinins in mice. Hektoen (2), Lawson (5), and Weszeczky (9) all failed to find isoagglutinins in guinea pigs. However, the discovery of factors such as M and N in human blood, and the recent work of Landsteiner and Miller (4), Landsteiner and Levine (3), and Todd (8) on chickens, and of Levine and Landsteiner (6) on rabbits, suggested the possibility that isoagglutinogens not accompanied by corresponding agglutinins might be found. Blood was taken from 8 guinea pigs, not completely alike genetically, as judged by coat and eye color.

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