Effects of Halogenated Hydrocarbon Anesthetics on Responses to Ligation of a Coronary Artery in Chronically Prepared Rats

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Abstract
Responses to ligation of the left anterior descending coronary artery (blood pressure, heart rate, ECG, arrhythmias, myocardial tissue loss and mortality) were investigated in chronically prepared rats anesthetized with one of various halogenated hydrocarbon anesthetics. Halothane (inhaled concentrations of 0, 0.25, 0.5, 1.0 and 2.0%) reduced arrhythmias, mortality, and S-T segment changes in the ECG in a dose-related manner. The most effective antiarrhythmic concentrations were 0.5 and 1.0%. Other halogenated hydrocarbon anesthetics (chloroform, enflurane, isoflurane, methoxyflurane and trichloroethylene) were investigated at minimal anesthetic concentrations. Of these, only chloroform and enflurane reduced arrthymias. Both increased mortality as a result of nonarrhythmic causes. At 1/2 anesthetic concentrations, chloroform (0.25%) and enflurane (0.75%) were not antiarrhythmic and mortality resulting from nonarrhythmic causes was not increased. In the chronically prepared rat, halothane at anesthetic and subanesthetic concentrations has antiarrhythmic actions against ligation-induced arrhythmias, reducing mortality. Of the other halogenated hydrocarbons tested, only enflurane and chloroform had antiarrhythmic actions; however, mortality was high with both agents because of accompanying cardiovascular depression.

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