Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women
Open Access
- 1 May 2004
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 85 (5) , 1237-1241
- https://doi.org/10.1099/vir.0.19694-0
Abstract
The prevalence of human papillomavirus type 16 E6 variant lineages was characterized in a cross-sectional study of 24 human immunodeficiency virus type 1 (HIV)-positive and 33 HIV-negative women in New Orleans. The European prototype was the predominant variant in the HIV-negative women (39·4 %), while in the HIV-positive women the European 350G variant was predominant (29·1 %). In exact logistic regression models, HIV-positive women were significantly more likely to harbour any variant with a nucleotide G-350 mutation compared with HIV-negative women [58·3 % vs 21·1 %; adjusted odds ratio (AOR)=6·28, 95 % confidence interval (CI)=1·19–46·54]. Models also revealed a trend towards increased prevalence of Asian–American lineage in HIV-positive women compared with HIV-negative women (25·0 % vs 6·0 %; AOR=6·35, 95 % CI=0·77–84·97). No association was observed between any variant and cytology or CD4 cell counts or HIV-1 viral loads. These observations reflect a difference in the distribution of HPV-16 variants among HIV-positive and -negative women, indicating that HIV-positive status may lead to increased prevalence of a subset of variants.Keywords
This publication has 27 references indexed in Scilit:
- Environmental co-factors in HPV carcinogenesisVirus Research, 2002
- Host and viral genetics and risk of cervical cancer: a reviewVirus Research, 2002
- Increased Risk of High?Grade Anal Neoplasia Associated with a Human Papillomavirus Type 16 E6 Sequence VariantThe Journal of Infectious Diseases, 2002
- Prevalence, Incidence, and Type‐Specific Persistence of Human Papillomavirus in Human Immunodeficiency Virus (HIV)–Positive and HIV‐Negative WomenThe Journal of Infectious Diseases, 2001
- Asian-American Variants of Human Papillomavirus 16 and Risk for Cervical Cancer: a Case-Control StudyJNCI Journal of the National Cancer Institute, 2001
- HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa RicaBritish Journal of Cancer, 2001
- Human papillomavirus variants and squamous neoplasia of the cervixThe Journal of Pathology, 2001
- Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesionsBritish Journal of Cancer, 2000
- Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide PerspectiveJNCI Journal of the National Cancer Institute, 1995
- The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancerNature Medicine, 1995