A Three Year Double Blind Investigation of the Effects of Lithium Carbonate on Serum Protein-Bound Iodine in Manic Depressive Patients
- 1 January 1975
- journal article
- clinical trial
- Published by S. Karger AG in Neuropsychobiology
- Vol. 1 (5) , 304-312
- https://doi.org/10.1159/000117504
Abstract
In a controlled investigation of the long-term effect of lithium on protein-bound iodine (PBI), 17 manic-depressive patients were placed on lithium for 6 months then shifted on a double blind basis to lithium (8 patients) and placebo (9 patients), and followed for a maximum of 3 years. Serum PBIs and lithium levels were evaluated initially and every 3 months thereafter. The placebo group showed no significant change in PBI during the first 6 months while still on lithium. At 9- and 12-month evaluations, a rise in serum PBI was noted. Seven placebo patients with data available displayed a mean 6-month PBI of 6.26 ± 0.67 µg% and at 9 months 7.07 ± 0.63 µg% (pKeywords
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