Preparation, Characterization, and Antiviral Activity of Microbial Metabolites of Stemodin

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Abstract
Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8 beta-hydroxystemodin [8], 8 beta, 18-dihydroxystemodin [9], and 7 beta, 8 beta-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.

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