Variation in immunoglobulin G and albumin concentrations during lumbar CSF removal
- 1 August 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 32 (8) , 893
- https://doi.org/10.1212/wnl.32.8.893
Abstract
We studied the variation in immunoglobulin G (IgG) and albumin concentrations in serial sampling of the first 25 ml of CSF during lumbar puncture (LP). A linear decremental gradient averaged 15% for both IgG and albumin. Both direction and magnitude of the gradient were unaffected by the position of the patient. In 12 patients with MS, the CSF IgG: albumin quotient was 5.5% greater when computed from the last aliquot, but this difference was not significant. These protein gradients affect the absolute concentrations but are not likely to affect the interpretation of immunoglobulin indices or electrophoresis patterns.This publication has 3 references indexed in Scilit:
- CSF Electrophoresis in One Thousand PatientsCanadian Journal of Neurological Sciences, 1980
- Variation of Immunoglobulin G and Total Protein Concentrations during Lumbar Cerebrospinal Fluid CollectionEuropean Neurology, 1979
- Factors Influencing the Concentration Gradient of Protein in Cerebrospinal Fluid12Journal of Clinical Investigation, 1958