DNA transport by a micromachined Brownian ratchet device
- 9 November 1999
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 96 (23) , 13165-13169
- https://doi.org/10.1073/pnas.96.23.13165
Abstract
We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50-mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a microscale lab-on-a-chip. A device with reduced feature size could produce a size-based separation of DNA molecules, with applications including the detection of single-nucleotide polymorphisms.Keywords
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This publication has 35 references indexed in Scilit:
- Brownian rectifiers: How to convert brownian motion into directed transportPublished by Springer Nature ,2008
- Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human GenomeScience, 1998
- Stochastic resonanceReviews of Modern Physics, 1998
- Sequencing the Human GenomeScience, 1997
- Modeling molecular motorsReviews of Modern Physics, 1997
- Bidirectional Transport of Polyelectrolytes Using Self-Modulating Entropic RatchetsPhysical Review Letters, 1997
- Precise Numerics versus Theory for Correlation RatchetsPhysical Review Letters, 1996
- Rectified motion of a mercury drop in an asymmetric structureEurophysics Letters, 1996
- Nonequilibrium fluctuation-induced transportPhysical Review Letters, 1994
- Fluctuation driven ratchets: Molecular motorsPhysical Review Letters, 1994