RADIOTELEMETRIC DETERMINATION OF GASTROINTESTINAL PH IN 4 HEALTHY BEAGLES

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 46  (7) , 1516-1521
Abstract
A radiotelemetric technique for monitoring canine gastrointestinal function with clinical and research applications is described. Continuous gastrointestinal pH profiles for base-line (fasted) and postprandial states were recorded for a 6-h test period in 4 beagles, using a radiotelemetric device (Heidelberg capsule). Base-line gastric pH values were between 0.9 and 2.5 during the first 30 min, with a mean .+-. SE of 1.5 .+-. 0.04. Postprandial gastric pH values varied between 0.5 and 3.5 during the first 30 min, with a mean of 2.1 .+-. 0.04. Base-line duodenal pH values during the initial 5 min after gastric emptying varied from 4.5 to 7.5 with a mean of 6.1 .+-. 0.1, and for the initial 60-min post-gastric emptying, pH ranged from 4.5 to greater than 8.0 (beyond capsule calibration limit) with a mean of 6.7 .+-. 0.05. The pH tended to increase linearly with time during the initial 60 min in the intestine. Mean gastric residence time of the capsule was 74 .+-. 26.5 min in the fasted state (range 0 to 240 min). Postprandially, the capsule remained in the stomach for the duration of the 6-h observation period.