Design and Optimization of Theophylline Pellets Obtained by Wet Spheronization in A High-Shear Mixer

1 January 1995

journal article
research article
Published by Taylor & Francis in Drug Development and Industrial Pharmacy

Vol. 21 (18) , 2129-2137
https://doi.org/10.3109/03639049509065896

Abstract

The pelletization of lactose, cellulose, polivinylpirrolidone and theophylline was carried out in a 101 high-shear mixer. The effect of impeller speed and the amount of binding solution was investigated on the characteristics of the pellets (percentage of pellets possessing a diameter in the interval 800 to 1250 μm and porous structure). Numerous experiments were performed using the experimental design methodology, in particular a Doehlert and simplex matrix combination.

Keywords

This publication has 4 references indexed in Scilit:

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