Midazolam-Alfentanil Synergism for Anesthetic Induction in Patients
- 1 August 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 69 (2) , 213???217-217
- https://doi.org/10.1213/00000539-198908000-00013
Abstract
The effect of midazolam on the induction dose-response curve for alfentanil was studied in nonpremedicated ASA physical status I or II patients. The response to the verbal command was used as an end point of anesthesia. Dose-response curves for midazolam, alfentanil, and their combination were determined with a probit procedure, and compared with algebraic (fractional) analysis of drug interaction. Interaction between midazolam and alfentanil was found to be synergistic (supraadditive). The results suggest that the use of this combination is advantageous not only because it helps to achieve different anesthetic goals with specific drugs (a benzodiazepine for unconsciousness and an opioid for blockade of the responses to noxious stimulation), but also because its components are complementary for unconsciousness.This publication has 1 reference indexed in Scilit:
- Notes on the use of propagation of error formulasJournal of Research of the National Bureau of Standards, Section C: Engineering and Instrumentation, 1966