Hyperbaric oxygen: the Medical Research Council trials and their clinical significance

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Abstract
The clinical trials of the use of hyperbaric O2 in radiotherapy conducted by the Medical Research Council''s working party have shown that local cure and surival can be improved in head and neck and cervical cancer. Evidence for benefit was presented in carcinoma of bronchus, but none has so far been found in carcinoma of the bladder. Although hyperbaric O2 has produced increased effect upon normal tissues as well as upon tumor, a real improvement in therapeutic ratio appears to be present. The future use of hyperbaric O2 in radiotherapy will depend upon a comparison of effectiveness with other methods now being tested to improve radiotherapy. The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.