EFFECTS OF (E)-1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL) PIPERAZINE DIHYDROCHLORIDE (FLUNARIZINE) ON CEREBRAL-CIRCULATION

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Abstract
Effects of flunarizine (0.3-3 mg/kg, i.v.) on cerebral circulation were compared with those of cinnarizine (0.3-3 mg/kg i.v.) and papaverine (0.1-1 mg/kg, i.v.) in anesthetized dogs and cats. In dogs all 3 drugs caused a dose-related increase in vertebral, common carotid and femoral arterial blood flow, while a transient decrease in renal blood flow was observed. The vasodilatation caused by flunarizine and cinnarizine was much more marked in the vertebral vascular beds. Flunarizine (10 and 30 mg/kg, intraduodenally) caused a greater and more prolonged increase in the vertebral blood flow than did cinnarizine and papaverine at the same doses. Concerning the local circulation in cats, flunarizine and cinnarizine produced a marked flow increase in the cerebellar cortex, apparent blood flow and pO2 [arterial O2 tension] increases in the cerebral cortex with no observable concomitant changes in arterial blood pO2 and pCO2 [arterial CO2 tension] but a slight decrease in hippocampal blood flow without any consistent effect in hypothalamic blood flow. Flunarizine had a more prolonged pharmacological activity on the responses of the cerebral circulation than did equal doses of cinnarizine or papaverine.

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