A Convenient Synthesis of N-Alkyl and N, N-Dialkyltrifluoroacetamides in a Solid-liquid Two-Phase System in the Presence of Phase-Transfer Catalysts
- 1 June 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (8) , 791-800
- https://doi.org/10.1080/00397918808057847
Abstract
Trifluoroacetamide is easily monoalkylated in a K2 CO3-organic solvent solid-liquid two-phase system affording in good to excellent yields N-alkyltrifluoroacetamides. Under the same conditions, the latter, in turn, react with alkylating agents giving N, N-dialkyltrifluoroacetamides in high yields.Keywords
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