Procainamide Accumulation Kinetics in the Immediate Postmyocardial Infarction Period

Publisher Website
Google Scholar
Abstract
The rate of change of plasma procainamide concentration during 36 h of constant-rate i.v. infusion was examined in 5 acute myocardial infarction patients. A steady-state plasma concentration was established in about 16 h, which is consistent with simulations of plasma concentrations based on pharmacokinetic constants obtained from studies in young healthy volunteers. The steady-state level that was attained in these patients was markedly higher than that which the simulations predicted. Acute myocardial infarction patients usually have lower total body clearances of procainamide than normal volunteers.