Pyrrolopyrimidine nucleosides. VI. Synthesis of 1,3 and 7‐β‐D‐ribofuranosylpyrrolo[2.3‐d] pyrimidines via silylated intermediates
- 1 August 1970
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 7 (4) , 799-806
- https://doi.org/10.1002/jhet.5570070408
Abstract
The ribosylation of several silylated pyrrolo[2,3‐d]pyrimidines by the Wittenberg procedure has produced 1,3 and 7‐ribosylpyrrolo[2,3‐d]pyrimidine derivatives in high yield. Structure assignments have been made on the basis of the ultraviolet spectra of model compounds and further confirmed by chemical conversion to derivatives of established structure. A convenient ribosylation procedure utilizing silver oxide, a halosugar, and a silylated pyrrolo[2,3‐d]pyrimidine derivative in acetonitrile has been described.Keywords
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